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| 6/1/2025 | RedSox Traded Tylor Megill to Cubs |
| 6/1/2025 | Cubs Traded Juan Yepez to RedSox |
| 6/1/2025 | Cubs Traded Emmanuel Clase to RedSox |
| 6/1/2025 | Indians Signed Kody Clemens |
| 6/1/2025 | RedSox Traded Brayan Bello to Cubs |
| 6/1/2025 | Rays Signed Eric Orze |
| 6/1/2025 | Indians Released Justin Sterner |
| 5/25/2025 | Tigers Released Craig Kimbrel |
| 5/25/2025 | Indians Signed Luis Torrens |
| 5/25/2025 | Tigers Released Brendan Rodgers |
| 5/25/2025 | RedSox Released Austin Martin |
| 5/25/2025 | Indians Released Matt Mervis |
| 5/25/2025 | Tigers Signed Logan Allen |
| 5/25/2025 | RedSox Signed Brett Baty |
| 5/25/2025 | Tigers Signed Louie Varland |
| 5/17/2025 | Rays Retired Evan Longoria |
| 5/17/2025 | Expos Signed Shelby Miller |
| 5/17/2025 | Royals Released Evan Phillips |
| 5/17/2025 | Expos Signed Jose Trevino |
| 5/17/2025 | Expos Signed Yoan Moncada |
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